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J Vet Intern Med. 2015 Nov-Dec;29(6):1473-8. doi: 10.1111/jvim.13603. Epub 2015 Aug 26.

Association of Vitamin D Status and Clinical Outcome in Dogs with a Chronic Enteropathy.

Author information

1
Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, Midlothian, UK.
2
Vitamin D Research Laboratory, Endocrinology and Diabetes, Institute of Human Development, University of Manchester, Manchester Academic Health Science Centre, Manchester Royal Infirmary, Manchester, UK.

Erratum in

Abstract

BACKGROUND:

Dogs with a chronic enteropathy (CE) have a lower vitamin D status, than do healthy dogs. Vitamin D status has been associated with a negative clinical outcome in humans with inflammatory bowel disease.

OBJECTIVES:

To examine the relationship between serum 25 hydroxyvitamin D (25(OH)D) concentrations at diagnosis and clinical outcome in dogs with a CE.

ANIMALS:

Forty-one dogs diagnosed with CE admitted to the Royal Dick School of Veterinary Studies, Hospital for Small Animals between 2007 and 2013.

METHODS:

Retrospective review. Serum 25(OH)D concentrations were compared between dogs which were alive at follow up or had died because of non-CE-related reasons (survivors) and dogs which died or were euthanized due to their CE (non-survivors). A binary logistic regression analysis was performed to determine significant predictors of death in dogs with CE.

RESULTS:

Serum concentrations of 25(OH)D at the time a CE was diagnosed were significantly lower in nonsurvivors (n = 15) (median nonsurvivors 4.36 ng/mL, interquartile range 1.6-17.0 ng/mL), median survivors (n = 26) (24.9 ng/mL interquartile range 15.63-39.45 ng/mL, P < .001). Serum 25(OH)D concentration was a significant predictor of death in dogs with CE (odds ratio 1.08 [95% CI 1.02-1.18)]).

CONCLUSIONS:

Serum 25(OH)D concentrations at diagnosis are predictive of outcome in dogs with CE. The role of vitamin D in the initiation and outcome of chronic enteropathies in dogs is deserving of further study.

KEYWORDS:

25 (OH)D; Inflammatory bowel disease; Prognostic

PMID:
26308876
PMCID:
PMC4895651
DOI:
10.1111/jvim.13603
[Indexed for MEDLINE]
Free PMC Article

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