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Int J Food Sci Nutr. 2015;66(6):603-10. doi: 10.3109/09637486.2015.1077796. Epub 2015 Aug 26.

Resveratrol and anti-atherogenic effects.

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a Cardiology Unit, San Camillo de Lellis Hospital , Manfredonia , Foggia , Italy .
b Clinical and Human Nutrition Unit, Department of Oral Medical and Biotechnological Sciences, University "G. D'Annunzio" , Chieti , Italy and.
c Department of Pediatric Cardiovascular Surgery , IRCCS San Donato Milanese Hospital , San Donato Milanese , Italy.


The role of inflammation and oxidative stress in atherosclerosis development has been increasingly well recognized over the past decade. Inflammation has a significant role at all stages of atherosclerosis, including initiation, progression and plaque formation. Resveratrol is a naturally occurring polyphenolic compound found in grape products, berry fruits and red wine. Its ability to behave therapeutically as a component of red wine has attracted wide attention. Accumulating evidence suggests that it is a highly pleiotropic molecule that modulates numerous targets and molecular functions. Epidemiological studies indicate that the Mediterranean diet, rich in resveratrol, is associated with a reduced risk of atherosclerosis. Resveratrol is believed to decrease circulating low-density lipoprotein cholesterol levels, reduce cardiovascular disease risk; it reduces lipid peroxidation, platelet aggregation and oxidative stress. Resveratrol is considered a safe compound, since no significant toxic effects have been demonstrated after administration of a broad range of concentrations, and an effective anti-atherogenic agent.


Anti-inflammatory; antioxidant; atherosclerosis; cardiovascular disease; lipids; polyphenol; prevention

[Indexed for MEDLINE]

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