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J Clin Virol. 2015 Sep;70:105-108. doi: 10.1016/j.jcv.2015.07.300. Epub 2015 Jul 26.

Asymptomatic children might transmit human parechovirus type 3 to neonates and young infants.

Author information

1
Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
2
Department of Pediatrics, Niigata Medicalcare Cooperative Kido Hospital, Niigata, Japan.
3
Department of Medical Technology, Niigata University Graduate School of Health Sciences, Niigata, Japan.
4
Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego, USA. Electronic address: asaitoh@med.niigata-u.ac.jp.

Abstract

BACKGROUND:

Human parechovirus type 3 (HPeV3) epidemics occur worldwide and can lead to severe disease in neonates and young infants. Little is known about the source of HPeV3 infection.

OBJECTIVES:

To investigate the source of HPeV3 infection and the role of asymptomatic children in the families of infected children.

STUDY DESIGN:

During a 2014 HPeV3 epidemic in Niigata, Japan, we analyzed (1) clinical information on sick contacts for 43 neonates and young infants with HPeV3-related disease diagnosed by PCR analysis of serum and/or cerebrospinal fluid and (2) stool samples from symptomatic and asymptomatic siblings/cousins of index patients. To confirm transmission, the P1 (VP0, VP3, and VP1) and 3D(pol) regions of HPeVs were sequenced and analyzed.

RESULTS:

Sick contact with family members was confirmed for 51% (n=22) of patients. Among the 30 symptomatic family members, 67% (n=20) were siblings, 20% (n=6) were mothers, and 13% (n=4) were other relatives. Stool samples from symptomatic and asymptomatic siblings/cousins of 4 HPeV3-infected patients yielded positive results for HPeVs on PCR analysis. Furthermore, the P1 and 3D(pol) nucleotide sequences of family members were 100% identical to those of the respective index cases.

CONCLUSIONS:

Identification of genetically identical virus from HPeV3-infected patients and asymptomatic children in their families suggests that the latter are a source of infection in neonates and young infants with HPeV3-related diseases.

KEYWORDS:

Asymptomatic siblings; Epidemic; Feces; Human parechovirus type 3; Neonates; Transmission

PMID:
26305831
DOI:
10.1016/j.jcv.2015.07.300
[Indexed for MEDLINE]

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