Format

Send to

Choose Destination
J Clin Virol. 2015 Sep;70:39-42. doi: 10.1016/j.jcv.2015.06.103. Epub 2015 Jun 29.

Hepatitis E virus seroprevalence in three hyperendemic areas: Nepal, Bangladesh and southwest France.

Author information

1
Université Toulouse III Paul Sabatier, Toulouse, France; Inserm, U1043, Toulouse, France; Hôpital Purpan, CHU de Toulouse, Toulouse, France.
2
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
3
Oxford University Clinical Research Unit\Patan Hospital, Kathmandu, Nepal.
4
University of Exeter, Truro, Cornwall, UK; Royal Cornwall Hospital Trust, Truro, Cornwall, UK.
5
Child Health Research Foundation, Department of Microbiology, Dhaka Shishu Hospital, Dhaka, Bangladesh.
6
cddr, b, Dhaka, Bangladesh.
7
Hôpital Purpan, CHU de Toulouse, Toulouse, France.
8
Université Toulouse III Paul Sabatier, Toulouse, France; Inserm, U1043, Toulouse, France; Hôpital Rangueil, CHU de Toulouse, Toulouse, France.

Abstract

BACKGROUND:

Hepatitis E causes a significant burden of disease in developing countries and has recently been increasingly recognized in developed countries. Comparing population anti-hepatitis E virus (HEV) seroprevalence across populations has been difficult.

OBJECTIVES:

The aim of this study was to compare the anti-HEV IgG seroprevalence in both adults and children in three hyper-endemic areas (Nepal, Bangladesh and southwest France) using a sensitive, commercial anti-HEV IgG assay.

STUDY DESIGN:

Serum or plasma from adults and children in Nepal (n=498), Bangladesh (n=1,009) and Southwest France (n=1031) were tested for anti-HEV IgG using the Wantai assay.

RESULTS:

After age-standardization, anti-HEV IgG seroprevalence was 47.1%, 49.8% and 34.0% in Nepal, Bangladesh and southwest France, respectively. There was no difference in seroprevalence by gender in any of the countries. A paucity of infections in children 1-10 years-old was consistently observed (less than 15%) at all 3 locations.

CONCLUSIONS:

Surprisingly similar high rates of anti-HEV antibodies were detected using a common, sensitive assay. Despite differences in the epidemiology and circulating genotype of HEV in Nepal, Bangladesh and southwest France, this study found more similarities in population seroprevalence than expected.

KEYWORDS:

Adult; Child; Hepatitis E Virus; Seroepidemiologic studies

PMID:
26305817
DOI:
10.1016/j.jcv.2015.06.103
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center