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Dev Cell. 2015 Aug 24;34(4):379-80. doi: 10.1016/j.devcel.2015.08.008.

A Phosphoinositide Code for Primary Cilia.

Author information

1
Department of Neurochemistry and Molecular Cell Biology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan. Electronic address: nakatsu@med.niigata-u.ac.jp.

Abstract

How phosphoinositide metabolism is coupled to primary cilia physiology is poorly understood. Reporting recently in Developmental Cell, Chávez et al. (2015) and Garcia-Gonzalo et al. (2015) show that INPP5E-mediated phosphoinositide metabolism, which creates a specific phosphoinositide distribution, ensures proper protein trafficking and Hh signaling in primary cilia.

PMID:
26305588
DOI:
10.1016/j.devcel.2015.08.008
[Indexed for MEDLINE]
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