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Am J Respir Crit Care Med. 2015 Dec 1;192(11):1366-72. doi: 10.1164/rccm.201505-0963WS.

Future Research Directions in Asthma. An NHLBI Working Group Report.

Author information

1
1 Brigham and Women's Hospital, Boston, Massachusetts.
2
2 National Heart, Lung, and Blood Institute, Bethesda, Maryland.
3
3 University of Connecticut Health Center, Hartford, Connecticut.
4
4 University of Rochester, Rochester, New York.
5
5 University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
6
6 The University of Chicago, Chicago, Illinois.
7
7 University of California at San Francisco, San Francisco, California.
8
8 Johns Hopkins University, Baltimore, Maryland.
9
9 National Jewish Health, Denver, Colorado.
10
10 Massachusetts General Hospital, Boston, Massachusetts.
11
11 Yale University School of Medicine, New Haven, Connecticut.
12
12 Emory University School of Medicine, Atlanta, Georgia.
13
13 Case Western Reserve University, Cleveland, Ohio.
14
14 Vanderbilt University School of Medicine, Nashville, Tennessee.
15
15 University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
16
16 Wake Forest School of Medicine, Winston Salem, North Carolina.
17
17 University of Arizona, Tucson, Arizona.
18
18 Stanford School of Medicine, Stanford, California.
19
19 Georgia Regents University, Augusta, Georgia.
20
20 Children's Hospital Colorado and the University of Colorado School of Medicine, Denver, Colorado.
21
21 Icahn School of Medicine at Mount Sinai, New York, New York; and.
22
22 Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio.

Abstract

Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation research. This report summarizes the workshop and produces recommendations to guide future research in asthma.

KEYWORDS:

asthma; disease modification; implementation; phenotype; prevention

PMID:
26305520
PMCID:
PMC4731702
DOI:
10.1164/rccm.201505-0963WS
[Indexed for MEDLINE]
Free PMC Article

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