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Schizophr Bull. 2016 Mar;42(2):318-26. doi: 10.1093/schbul/sbv114. Epub 2015 Aug 24.

Effects of Fronto-Temporal Transcranial Direct Current Stimulation on Auditory Verbal Hallucinations and Resting-State Functional Connectivity of the Left Temporo-Parietal Junction in Patients With Schizophrenia.

Author information

1
EA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France;
2
Laboratoire de Sciences Cognitives & Affectives (SCA-Lab), UMR CNRS 9193, Université de Lille & CURE, Hôpital Fontan, CHRU de Lille, F-59000, Lille, France.
3
EA4615, Université de Lyon & CH Le Vinatier, F-69678 Bron, France; jerome.brunelin@ch-le-vinatier.fr.

Abstract

Auditory verbal hallucinations (AVH) in patients with schizophrenia are associated with abnormal hyperactivity in the left temporo-parietal junction (TPJ) and abnormal connectivity between frontal and temporal areas. Recent findings suggest that fronto-temporal transcranial Direct Current stimulation (tDCS) with the cathode placed over the left TPJ and the anode over the left prefrontal cortex can alleviate treatment-resistant AVH in patients with schizophrenia. However, brain correlates of the AVH reduction are unclear. Here, we investigated the effect of tDCS on the resting-state functional connectivity (rs-FC) of the left TPJ. Twenty-three patients with schizophrenia and treatment-resistant AVH were randomly allocated to receive 10 sessions of active (2 mA, 20 min) or sham tDCS (2 sessions/d for 5 d). We compared the rs-FC of the left TPJ between patients before and after they received active or sham tDCS. Relative to sham tDCS, active tDCS significantly reduced AVH as well as the negative symptoms. Active tDCS also reduced rs-FC of the left TPJ with the left anterior insula and the right inferior frontal gyrus and increased rs-FC of the left TPJ with the left angular gyrus, the left dorsolateral prefrontal cortex and the precuneus. The reduction of AVH severity was correlated with the reduction of the rs-FC between the left TPJ and the left anterior insula. These findings suggest that the reduction of AVH induced by tDCS is associated with a modulation of the rs-FC within an AVH-related brain network, including brain areas involved in inner speech production and monitoring.

KEYWORDS:

brain stimulation; fMRI; resting state; temporal cortex

PMID:
26303936
PMCID:
PMC4753593
DOI:
10.1093/schbul/sbv114
[Indexed for MEDLINE]
Free PMC Article

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