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BMC Complement Altern Med. 2015 Aug 25;15:294. doi: 10.1186/s12906-015-0814-1.

The effects of Malaysian propolis and Brazilian red propolis on connective tissue fibroblasts in the wound healing process.

Author information

1
School of Medicine, International Medical University, Kuala Lumpur, Malaysia. annjacob.aj90@gmail.com.
2
School of Dentistry, International Medical University, Kuala Lumpur, Malaysia. abhishek_parolia@imu.edu.my.
3
School of Dentistry, International Medical University, Kuala Lumpur, Malaysia. allan_pau@imu.edu.my.
4
School of Human Biology, International Medical University, Kuala Lumpur, Malaysia. fabian_davamani@imu.edu.my.

Abstract

BACKGROUND:

To evaluate and compare the effects of ethanolic extracts of Malaysian propolis and Brazilian red propolis at different concentrations on the migration and proliferation of fibroblast cells.

METHODS:

Malaysian and Brazilian red propolis crude samples were extracted using ethanol. Their wound healing effects were tested in vitro on the normal human fibroblast cell line CRL-7522. Cell migration and proliferation assays were carried out using propolis concentrations of 1, 10, 100, 250, 500 and 1000 μg/mL. The data were analyzed using one-way ANOVA and post hoc Bonferroni tests (α=0.05).

RESULTS:

Malaysian and Brazilian red propolis followed a concentration-dependent increasing and decreasing trend. Malaysian propolis showed the fastest migration rate at 250 μg/mL which was statistically significant (p<0.05) and maximum proliferation at 500 μg/mL with no significant difference (p>0.05) compared to control. Brazilian red propolis showed a slight increase in migration and proliferation at 10 and 100 μg/mL, respectively with no significant difference (p>0.05) compared to control, while concentrations above these conferred inhibitory effects.

CONCLUSION:

Malaysian and Brazilian red propolis show potential to assist in wound healing, depending on their concentration.

PMID:
26303848
PMCID:
PMC4549008
DOI:
10.1186/s12906-015-0814-1
[Indexed for MEDLINE]
Free PMC Article

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