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Genome Biol. 2015 Aug 25;16:174. doi: 10.1186/s13059-015-0747-5.

Chromatin states and nuclear organization in development--a view from the nuclear lamina.

Author information

1
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland. anna.mattout@fmi.ch.
2
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland. daphne.cabianca@fmi.ch.
3
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland. susan.gasser@fmi.ch.
4
University of Basel, Faculty of Natural Sciences, Klingelbergstrasse 50, CH-4056, Basel, Switzerland. susan.gasser@fmi.ch.

Abstract

The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.

PMID:
26303512
PMCID:
PMC4549078
DOI:
10.1186/s13059-015-0747-5
[Indexed for MEDLINE]
Free PMC Article
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