Format

Send to

Choose Destination
J Trace Elem Med Biol. 2015 Oct;32:66-72. doi: 10.1016/j.jtemb.2015.05.006. Epub 2015 May 28.

Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study.

Author information

1
Post-Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petrópolis, Natal-RN CEP 59012-570, Brazil. Electronic address: ananpaiva@gmail.com.
2
Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN), Avenida: Nilo Peçanha, 620, Petrópolis, Natal-RN CEP 59012-300, Brazil. Electronic address: josivanlima@gmail.com.
3
Health Sciences College of Trairi, Federal University of Rio Grande do Norte (UFRN) Rua Trairí, S/N-Centro-Santa Cruz/RN, CEP 59200-000, Brazil. Electronic address: annacqm@yahoo.com.br.
4
Graduate Student in the Department of Nutrition, Federal University of Rio Grande do Norte (UFRN), Av. Senador Salgado Filho, 3000 Lagoa Nova, Natal-RN CEP 59078-970, Brazil. Electronic address: figueiredoheverton@gmail.com.
5
Graduate Student in the Department of Nutrition, Federal University of Rio Grande do Norte (UFRN), Av. Senador Salgado Filho, 3000 Lagoa Nova, Natal-RN CEP 59078-970, Brazil. Electronic address: raianalourenco.a@hotmail.com.
6
Post Doctoral Fellow in the Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petrópolis, Natal-RN CEP 59012-570, Brazil. Electronic address: marcelaururahy@yahoo.com.br.
7
Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petrópolis, Natal-RN CEP 59012-570, Brazil. Electronic address: adrirezende@yahoo.com.
8
Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN), Avenida: Nilo Peçanha, 620, Petrópolis, Natal-RN CEP 59012-300, Brazil. Electronic address: brandao-neto@live.com.
9
Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petrópolis, Natal-RN CEP 59012-570, Brazil. Electronic address: mgalmeida84@gmail.com.

Abstract

BACKGROUND:

Chromium is an essential mineral that contributes to normal glucose function and lipid metabolism. This study evaluated the effect of chromium picolinate (CrPic) supplementation in patients with type 2 diabetes mellitus (T2DM).

METHODS:

A four month controlled, single blind, randomized trial was performed with 71 patients with poorly controlled (hemoglobin A1c [HbA1c]>7%) T2DM divided into 2 groups: Control (n=39, using placebo), and supplemented (n=32, using 600μg/day CrPic). All patients received nutritional guidance according to the American Diabetes Association (ADA), and kept using prescribed medications. Fasting and postprandial glucose, HbA1c, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides and serum ferritin were evaluated.

RESULTS:

CrPic supplementation significantly reduced the fasting glucose concentration (-31.0mg/dL supplemented group; -14.0mg/dL control group; p<0.05, post- vs. pre-treatment, in each group) and postprandial glucose concentration (-37.0mg/dL in the supplemented group; -11.5 mg/dL in the control group; p<0.05). HbA1c values were also significantly reduced in both groups (p<0.001, comparing post- vs. pre-treatment groups). Post-treatment HbA1c values in supplemented patients were significantly lower than those of control patients. HbA1c lowering in the supplemented group (-1.90), and in the control group (-1.00), was also significant, comparing pre- and post-treatment values, for each group (p<0.001 and p<0.05, respectively). CrPic increased serum chromium concentrations (p<0.001), when comparing the supplemented group before and after supplementation. No significant difference in lipid profile was observed in the supplemented group; however, total cholesterol, HDL-c and LDL-c were significantly lowered, comparing pre- and post-treatment period, in the control group (p<0.05).

CONCLUSIONS:

CrPic supplementation had a beneficial effect on glycemic control in patients with poorly controlled T2DM, without affecting the lipid profile. Additional studies are necessary to investigate the effect of long-term CrPic supplementation.

KEYWORDS:

Chromium picolinate; Dietary supplements; Dyslipidemia; Type 2 diabetes mellitus

PMID:
26302914
DOI:
10.1016/j.jtemb.2015.05.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center