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Exp Mol Pathol. 2015 Dec;99(3):533-6. doi: 10.1016/j.yexmp.2015.07.004. Epub 2015 Aug 21.

Finding mouse models of human lymphomas and leukemia's using the Jackson laboratory mouse tumor biology database.

Author information

  • 1The Jackson Laboratory, Bar Harbor, ME USA. Electronic address: dale.begley@jax.org.
  • 2The Jackson Laboratory, Bar Harbor, ME USA.
  • 3Virology and Cellular Immunology Section, Laboratory of Immunogenetics, NIAID, NIH, Bethesda, MD USA.
  • 4Global VetPathology, Montgomery Village, MD USA.

Abstract

Many mouse models have been created to study hematopoietic cancer types. There are over thirty hematopoietic tumor types and subtypes, both human and mouse, with various origins, characteristics and clinical prognoses. Determining the specific type of hematopoietic lesion produced in a mouse model and identifying mouse models that correspond to the human subtypes of these lesions has been a continuing challenge for the scientific community. The Mouse Tumor Biology Database (MTB; http://tumor.informatics.jax.org) is designed to facilitate use of mouse models of human cancer by providing detailed histopathologic and molecular information on lymphoma subtypes, including expertly annotated, on line, whole slide scans, and providing a repository for storing information on and querying these data for specific lymphoma models.

KEYWORDS:

Digital slides; Leukemia; Lymphoma; Mice; Mouse tumor biology database; Virtual slides

PMID:
26302176
PMCID:
PMC4679566
DOI:
10.1016/j.yexmp.2015.07.004
[PubMed - indexed for MEDLINE]
Free PMC Article
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