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Atherosclerosis. 2015 Oct;242(2):529-34. doi: 10.1016/j.atherosclerosis.2015.08.020. Epub 2015 Aug 14.

Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: the GCKD study.

Author information

1
Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
2
Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany.
3
Division of Nephrology, Department of Medicine, University Medical Center Freiburg, Freiburg, Germany.
4
Chair of Medical Informatics, University of Erlangen-Nürnberg, Erlangen, Germany.
5
Institute of Human Genetics, University of Erlangen-Nürnberg, Erlangen, Germany.
6
Division of Nephrology, Department of Medicine, University of Würzburg, Würzburg, Germany.
7
Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: Florian.Kronenberg@i-med.ac.at.

Abstract

BACKGROUND:

Chronic kidney disease (CKD) affects 10-15% of the general population and affected individuals are at an increased risk for cardiovascular disease (CVD). Since telomere length is considered to be involved in biological aging, we tested whether relative telomere length (RTL) might be a marker for these two diseases.

METHODS:

The German Chronic Kidney Disease (GCKD) study is an ongoing prospective cohort study including patients with CKD of moderate severity. RTL was measured by qPCR in 4955 out of 5217 GCKD patients at baseline.

RESULTS:

RTL was distributed in the cohort with a mean ± SD of 0.95 ± 0.19. CVD was present in 1266 patients. Each decrease of RTL by 0.1 unit was associated with a higher probability for prevalent CVD: OR = 1.06, 95% CI 1.02-1.11, p = 0.007 (adjusted for age, sex, eGFR, BMI, ln-CRP, smoking, hypertension, diabetes, and lipids). Similar findings were observed for history of specific CVD entities, such as coronary artery disease (OR = 1.05, p = 0.025), myocardial infarction (OR = 1.08, p = 0.013) and percutaneous transluminal coronary angioplasty (OR = 1.06, p = 0.032). The strongest associations were found for interventions at the carotid arteries (OR = 1.25, p = 0.001) as well as aortic aneurysms (OR = 1.22, p = 0.001).

CONCLUSIONS:

In the presence of CKD there is a significant association between shorter RTL and CVD manifestations. RTL appears to be a marker reflecting changes in homeostasis associated with CKD that may contribute to the excess CVD risk.

KEYWORDS:

Cardiovascular disease; Chronic kidney disease; High-risk population; Telomere length

[Indexed for MEDLINE]

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