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Brain Res. 2016 May 1;1638(Pt B):116-128. doi: 10.1016/j.brainres.2015.08.013. Epub 2015 Aug 21.

Lineage, fate, and fate potential of NG2-glia.

Author information

1
Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06268, USA. Electronic address: akiko.nishiyama@uconn.edu.
2
Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06268, USA.
3
Biotechnology and Bioservices Center, University of Connecticut, 75 North Eagleville Road, Unit 3156, Storrs, CT 06268, USA.

Abstract

NG2 cells represent a fourth major glial cell population in the mammalian central nervous system (CNS). They arise from discrete germinal zones in mid-gestation embryos and expand to occupy the entire CNS parenchyma. Genetic fate mapping studies have shown that oligodendrocytes and a subpopulation of ventral protoplasmic astrocytes arise from NG2 cells. This review describes recent findings on the fate and fate potential of NG2 cells under physiological and pathological conditions. We discuss age-dependent changes in the fate and fate potential of NG2 cells and possible mechanisms that could be involved in restricting their oligodendrocyte differentiation or fate plasticity. This article is part of a Special Issue entitled SI:NG2-glia(Invited only).

KEYWORDS:

Cell fate; Lineage; Myelin; NG2; Oligodendrocyte; Polydendrocyte

PMID:
26301825
PMCID:
PMC4761528
DOI:
10.1016/j.brainres.2015.08.013
[Indexed for MEDLINE]
Free PMC Article

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