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Plast Reconstr Surg Glob Open. 2015 Aug 10;3(7):e466. doi: 10.1097/GOX.0000000000000423. eCollection 2015 Jul.

Treatment of HIV-Infected Subjects with Buttock Lipoatrophy Using Stabilized Hyaluronic Acid Gel.

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Department of Plastic and Reconstructive Surgery, Hospital Henri Mondor, Créteil, France; Department of Reconstructive and Esthetic Plastic Surgery, Hospital Européen Georges Pompidou, Paris, France; and AP-HP, Groupe Henri-Mondor Albert-Chenevier, Imagerie Medicale, Créteil, France.


This prospective study explored effectiveness and safety of Macrolane VRF30 for treatment of buttock lipoatrophy in HIV-infected subjects. Ten subjects who were unable to sit for more than 30 minutes because of pain were injected with a mean of 276 mL and followed for 18 months. The pain score was reduced, and the time that subjects could sit was increased at least up to 9 months post treatment. There was no local displacement of gel. Five mild adverse events occurred; all related to the injection procedure. This pilot study indicates that Macrolane treatment of buttock lipoatrophy is a promising, well-tolerated method that reduces pain at sitting and improves buttock appearance.

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