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Hepat Mon. 2015 Jul 22;15(7):e28287. doi: 10.5812/hepatmon.28287v2. eCollection 2015 Jul.

Impact of the IL-10 Promoter Gene Polymorphisms in the Severity of Chronic Hepatitis B Infection.

Author information

1
Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Tehran, IR Iran ; Department of Otolaryngology and Head and Neck Surgery, Rasool Akram Hospital, Tehran, IR Iran.
2
Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Tehran, IR Iran ; Middle East Liver Disease Center (MELD), Tehran, IR Iran.
3
Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL), Tehran, IR Iran.

Abstract

BACKGROUND:

Interleukin-10 (IL-10) is an important anti-inflammatory cytokine. The polymorphisms of its promoter gene have been considered to be related with the chronicity of hepatitis B infection.

OBJECTIVES:

The aim of this study was to evaluate the polymorphisms at different positions in the IL-10 promoter gene in patients with chronic hepatitis B.

PATIENTS AND METHODS:

Totally, 166 patients with chronic hepatitis B infection were enrolled. Genotypes at different positions (i.e. -819, - 592, and - 1082) in the IL-10 gene promoter were determined.

RESULTS:

The C/A genotype at position -592, C/T genotype at position -819, and GCC/ATA haplotype of the IL-10 gene promoter were significantly more common in the patients with cirrhosis. The genotypes were significantly different between the hepatitis B e antigen (HBeAg)-negative and HBeAg-positive patients at position -592 (C/A and C/C), position -819 (C/C and C/T), and position -1082 (A/A and G/A).

CONCLUSIONS:

Some IL-10 promoter gene polymorphisms predisposed the infected hepatitis B virus cases to cirrhosis in our study population.

KEYWORDS:

Genotype; Interleukin-10; Liver Cirrhosis; Polymorphism, Genetic; Promoter Regions, Genetic

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