Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Cell Neurosci. 2015 Aug 5;9:302. doi: 10.3389/fncel.2015.00302. eCollection 2015.

Sympathoadrenergic modulation of hematopoiesis: a review of available evidence and of therapeutic perspectives.

Author information

1
Center for Research in Medical Pharmacology, University of Insubria Varese, Italy.

Abstract

Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradrenaline and possibly also dopamine, which act on adrenoceptors and dopaminergic receptors (DR) expressed on hematopoietic cells and affect cell survival, proliferation, migration and engraftment ability. Remarkably, dysregulation of adrenergic fibers to the BM is associated with hematopoietic disturbances and myeloproliferative disease. Several adrenergic and dopaminergic agents are already in clinical use for non-hematological indications and with a usually favorable risk-benefit profile, and are therefore potential candidates for non-conventional modulation of hematopoiesis.

KEYWORDS:

adrenaline; adrenoceptors; dopamine; dopaminergic receptors; drug repurposing; hematopoiesis; neuroimmune phamacology; noradrenaline

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center