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J Asthma. 2015;52(10):981-8. doi: 10.3109/02770903.2015.1044251. Epub 2015 Aug 21.

IL-17 polymorphisms and asthma risk: a meta-analysis of 11 single nucleotide polymorphisms.

Author information

1
a Department of Respiratory Disease , Taizhou Municipal Hospital , Taizhou , China and.
2
b Department of Respiratory Medicine , Affiliated Hospital of School of Medicine, Ningbo University , Ningbo , China.

Abstract

OBJECTIVE:

There has been significant interest in the association between asthma and the polymorphisms of IL-17A and IL-17F for a period of time. This work aims to present a clearer relationship between asthma and the polymorphisms of IL-17A and IL-17F.

METHOD:

Searches were performed in Medline, EMBASE, and the Chinese National Knowledge Infrastructure (CNKI) databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the relationship between polymorphisms of IL-17A and IL-17F and asthma.

RESULTS:

Nine studies comprising 3650 asthmatics and 3370 controls were included in this meta-analysis for all single nucleotide polymorphisms (SNPs) (2-6 per SNP). Our study examined the polymorphisms of IL-17F rs1889570 (C/T) (CC versus TT: OR = 0.55, 95%CI = 0.41-0.75; CT versus TT: OR = 0.54, 95%CI = 0.40-0.72; CC/CT versus TT: OR = 0.55, 95%CI = 0.42-0.72; CC versus CT/TT, OR = 1.83, 95%CI = 1.39-2.41), IL-17A rs4711998(A/G) (AA/AG versus GG: OR = 0.67, 95%CI = 0.46-0.98), and IL-17A rs3819024(A/G) (AA versus GG: OR = 1.77, 95%CI = 1.39-2.25) and found they were significantly related to the risk of asthma.

CONCLUSION:

Our systematic review showed that IL-17F rs1889570(C/T), IL-17A rs4711998(A/G) and IL-17A rs3819024(A/G) may be potential risk factors for asthma susceptibility.

KEYWORDS:

Asthma; IL-17A; IL-17F; meta-analysis; polymorphism

PMID:
26300019
DOI:
10.3109/02770903.2015.1044251
[Indexed for MEDLINE]

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