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Neuroimage. 2016 Feb 15;127:196-202. doi: 10.1016/j.neuroimage.2015.08.013. Epub 2015 Aug 20.

Functional connectivity MRI tracks memory networks after maze learning in rodents.

Author information

MRI Group, Singapore Bioimaging Consortium, A*STAR, Singapore.
Psychology, National Cheng-Kung University, Tainan, Taiwan.
Psychology, Neurobiology and Physiology, Northwestern University, Evanston, IL, USA; Physiology, Feinberg School of Medicine Northwestern University, Chicago, IL, USA.
MRI Group, Singapore Bioimaging Consortium, A*STAR, Singapore; Clinical Imaging Research Centre, National University of Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:


Learning and memory employs a series of cognitive processes which require the coordination of multiple areas across the brain. However in vivo imaging of cognitive function has been challenging in rodents. Since these processes involve synchronous firing among different brain loci we explored functional connectivity imaging with resting-state fMRI. After 5-day training on a hidden platform watermaze task, notable signal correlations were seen between the hippocampal CA3 and other structures, including thalamus, septum and cingulate cortex, compared to swim control or naïve animals. The connectivity sustained 7 days after training and was reorganized toward the cortex, consistent with views of memory trace distribution leading to memory consolidation. These data demonstrates that, after a cognitive task, altered functional connectivity can be detected in the subsequently sedated rodent using in vivo imaging. This approach paves the way to understand dynamics of area-dependent distribution processes in animal models of cognition.


Functional connectivity; Learning and memory; MRI; Morris water maze; Neural plasticity; Resting state

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