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Enzymes. 2015;37:111-37. doi: 10.1016/bs.enz.2015.06.001. Epub 2015 Jul 7.

Mechanisms of the Anticancer Effects of Isothiocyanates.

Author information

1
Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas, USA.
2
Cancer Preventive Material Development Research Center, College of Korean Medicine, Department of Pathology, Kyung Hee University, Seoul, South Korea. Electronic address: sungkim7@khu.ac.kr.
3
Department of Biomedical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, Amarillo, Texas, USA; Cancer Preventive Material Development Research Center, College of Korean Medicine, Department of Pathology, Kyung Hee University, Seoul, South Korea. Electronic address: sanjay.srivastava@ttuhsc.edu.

Abstract

Cancer results from aberrant signaling pathways that result in uncontrolled cellular proliferation. The epidemiological studies have shown a strong inverse correlation between dietary consumption of cruciferous vegetables and incidences of cancer. Isothiocyanates (ITCs) are present in cruciferous vegetables like broccoli, cabbage, watercress, etc. and are identified as the major active constituents. Several mechanistic studies have demonstrated chemopreventive and chemotherapeutic activity of ITCs against various tumor types. ITCs exert anticancer activity by suppressing various critical hallmarks of cancer like cellular proliferation, angiogenesis, apoptosis, metastasis, etc., in vitro as well as in preclinical animal model. ITCs also generate reactive oxygen species to induce apoptosis in cancer cells. Due to promising preclinical results, few ITCs have also advanced to clinical trials. This chapter provides a candid review on the chemopreventive and chemotherapeutic activity of various major ITCs.

KEYWORDS:

BITC; Cancer; Isothiocyanate; PEITC; Sulforaphane

PMID:
26298458
DOI:
10.1016/bs.enz.2015.06.001

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