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J Neuroimmunol. 2015 Sep 15;286:33-41. doi: 10.1016/j.jneuroim.2015.07.003. Epub 2015 Jul 11.

Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma.

Author information

1
School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, United States; NIEHS Center for Children's Environmental Health, University of California, Davis, United States. Electronic address: mdeloi@ucdavis.edu.
2
NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States; School of Public Health Sciences, University of California, Davis, United States.
3
The M.I.N.D. Institute, University of California, Davis, United States; School of Public Health Sciences, University of California, Davis, United States.
4
School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States.
5
NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States; School of Medicine, Department of Microbiology and Immunology, United States.
6
NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States; Department of Pediatrics, School of Medicine, University of California, Davis, United States.
7
School of Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, United States; NIEHS Center for Children's Environmental Health, University of California, Davis, United States; The M.I.N.D. Institute, University of California, Davis, United States.

Abstract

Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.

KEYWORDS:

Asthma; Autism; Food allergies; IL-17

PMID:
26298322
PMCID:
PMC4548834
DOI:
10.1016/j.jneuroim.2015.07.003
[Indexed for MEDLINE]
Free PMC Article

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