Format

Send to

Choose Destination
Pathog Dis. 2015 Nov;73(8):ftv064. doi: 10.1093/femspd/ftv064. Epub 2015 Aug 21.

Bordetella pertussis evolution in the (functional) genomics era.

Author information

1
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
2
Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK a.preston@bath.ac.uk.

Abstract

The incidence of whooping cough caused by Bordetella pertussis in many developed countries has risen dramatically in recent years. This has been linked to the use of an acellular pertussis vaccine. In addition, it is thought that B. pertussis is adapting under acellular vaccine mediated immune selection pressure, towards vaccine escape. Genomics-based approaches have revolutionized the ability to resolve the fine structure of the global B. pertussis population and its evolution during the era of vaccination. Here, we discuss the current picture of B. pertussis evolution and diversity in the light of the current resurgence, highlight import questions raised by recent studies in this area and discuss the role that functional genomics can play in addressing current knowledge gaps.

KEYWORDS:

Bordetella pertussis; diversity; evolution; genomics

PMID:
26297914
PMCID:
PMC4626590
DOI:
10.1093/femspd/ftv064
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center