Format

Send to

Choose Destination
J Immunol. 2015 Sep 1;195(5):1933-7. doi: 10.4049/jimmunol.1501209.

Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity.

Author information

1
Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; Department of Biomedical Science, National Jewish Health, Denver, CO 80206; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045; rubtsovak@njhealth.org.
2
Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; Department of Biomedical Science, National Jewish Health, Denver, CO 80206; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045;
3
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;
4
Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; Department of Biomedical Science, National Jewish Health, Denver, CO 80206; Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045; Department of Medicine, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045; and Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045.

Abstract

A newly discovered B cell subset, age-associated B cells, expresses the transcription factor T-bet, has a unique surface phenotype, and accumulates progressively with age. Moreover, B cells with these general features are associated with viral infections and autoimmunity in both mice and humans. In this article, we review current understanding of the characteristics, origins, and functions of these cells. We also suggest that the protective versus pathogenic actions of these cells reflect appropriate versus aberrant engagement of regulatory mechanisms that control the Ab responses to nucleic acid-containing Ags.

PMID:
26297793
PMCID:
PMC4548292
DOI:
10.4049/jimmunol.1501209
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center