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Rev Clin Esp. 2015 Dec;215(9):486-94. doi: 10.1016/j.rce.2015.07.002. Epub 2015 Aug 18.

Red wine intake but not other alcoholic beverages increases total antioxidant capacity and improves pro-inflammatory profile after an oral fat diet in healthy volunteers.

[Article in English, Spanish]

Author information

1
Internal Medicine, Hospital Gregorio Marañón, Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain; Instituto de investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
2
Department of Physiology, School of Medicine, Universidad Complutense, Madrid, Spain; Instituto de investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
3
Instituto Biología y Genética Molecular, CSIC-UVA, Valladolid, Spain.
4
Internal Medicine, Hospital Gregorio Marañón, Department of Medicine, School of Medicine, Universidad Complutense, Madrid, Spain; Instituto de investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain. Electronic address: lalvarezsalaw@gmail.com.

Abstract

INTRODUCTION:

Different alcoholic beverages exert different effects on inflammation and oxidative stress but these results are controversial and scanty in some aspects. We analyze the effect of different alcoholic beverages after a fat-enriched diet on lipid profile, inflammatory factors and oxidative stress in healthy people in a controlled environment.

METHODS:

We have performed a cross-over design in five different weeks. Sixteen healthy volunteers have received the same oral fat-enriched diet (1486kcal/m(2)) and a daily total amount of 16g/m(2) of alcohol, of different beverages (red wine, vodka, brandy or rum) and equivalent caloric intakes as sugar with water in the control group. We have measured the levels of serum lipids, high sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNFα), interleukin 6 (IL-6), soluble phospholipase A2 (sPLA2), lipid peroxidation (LPO) and total antioxidant capacity (TAC).

RESULTS:

Red wine intake was associated with decreased of mean concentrations of hsCRP, TNFα and IL-6 induced by fat-enriched diet (p<0.05); nevertheless, sPLA2 concentrations were not significantly modified. After a fat-enriched diet added with red wine, TAC increased as compared to the same diet supplemented with rum, brandy, vodka or the control (water with sugar) (p<0.05).

CONCLUSIONS:

Moderate red wine intake, but not other alcoholic beverages, decreased pro-inflammatory factors and increased total antioxidant capacity despite a fat-enriched diet intake in healthy young volunteers.

KEYWORDS:

Alcohol intake; Consumo de alcohol; Dieta rica en grasas; Estrés oxidativo; Inflamación; Inflammation; Oral fat diet; Oxidative stress

PMID:
26297333
DOI:
10.1016/j.rce.2015.07.002

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