Format

Send to

Choose Destination
See comment in PubMed Commons below
Fitoterapia. 2015 Oct;106:55-61. doi: 10.1016/j.fitote.2015.08.004. Epub 2015 Aug 18.

Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ).

Author information

1
Analytical Sciences, Amway Corporation, 7575 East Fulton Avenue, Ada, MI 49355, United States. Electronic address: john.rebhun@Amway.com.
2
Analytical Sciences, Amway Corporation, 7575 East Fulton Avenue, Ada, MI 49355, United States.

Abstract

Licorice, the root and stolons of the Glycyrrhiza plant (Fabaceae), has been used for centuries as a food additive (sweetener), in cosmetics, and in traditional medicine. In this research, we provide evidence that licorice extract activates peroxisome proliferator-activated receptor gamma (PPARγ) and, as identified through HPLC fractionation and mass spectroscopy, one of the activating phytochemicals is glabridin. Glabridin was shown to bind to and activate PPARγ. It was also shown to activate PPARγ-regulated gene expression in human hepatoma cells similar to known PPARγ ligands and that the expression was blocked by a PPARγ specific antagonist.

KEYWORDS:

Glabrene; Glabridin; Glycyrrhetinic acid; Glycyrrhiza glabra L; Glycyrrhizin; Licorice; Licorice extract; Peroxisome proliferator-activated receptor gamma (PPARγ); T0070907; Troglitazone

PMID:
26297329
DOI:
10.1016/j.fitote.2015.08.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center