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Nat Rev Mol Cell Biol. 2015 Sep;16(9):519-32. doi: 10.1038/nrm4043.

DNA methylation pathways and their crosstalk with histone methylation.

Author information

1
Shanghai Center for Plant Stress Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China.
2
Howard Hughes Medical Institute and Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, California 90095, USA.
3
Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Abstract

Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.

PMID:
26296162
PMCID:
PMC4672940
DOI:
10.1038/nrm4043
[Indexed for MEDLINE]
Free PMC Article

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