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Redox Biol. 2015 Dec;6:260-271. doi: 10.1016/j.redox.2015.08.010. Epub 2015 Aug 11.

Calcium and ROS: A mutual interplay.

Author information

1
Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. Electronic address: goerlach@dhm.mhn.de.
2
Experimental and Molecular Pediatric Cardiology, German Heart Center Munich at the Technical University Munich, Germany.
3
Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia.
4
Center for Molecular Medicine, Slovak Academy of Sciences, Bratislava, Slovakia; Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address: olga.krizanova@savba.sk.

Abstract

Calcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca(2+) signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules involved in various cellular processes including growth and cell death. Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks. However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders.

KEYWORDS:

Calcium; Channels; Endoplasmic reticulum; Mitochondria; NADPH oxidases; Reactive oxygen species

PMID:
26296072
PMCID:
PMC4556774
DOI:
10.1016/j.redox.2015.08.010
[Indexed for MEDLINE]
Free PMC Article

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