Format

Send to

Choose Destination
J Clin Pathol. 2016 Mar;69(3):215-20. doi: 10.1136/jclinpath-2015-203042. Epub 2015 Aug 20.

AGXT2L1 is down-regulated in heptocellular carcinoma and associated with abnormal lipogenesis.

Author information

1
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
2
Department of Immunology, School of Basic Medicine, Wuhan University, Wuhan, China.
3
Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China.
4
Department of Math and Statistics, Liberal Arts College, Portland State University, Portland, OR, USA.
5
Department of Hepatobiliary and Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Abstract

AIMS:

To clarify the clinical implications and functional role of the alanine-glyoxylate aminotransferase 2-like 1 (AGXT2L1) gene in hepatocellular carcinoma (HCC).

METHODS AND RESULTS:

We confirmed that AGXT2L1 was down-regulated in liver cancer samples by immunohistochemical (IHC) staining. We also demonstrated that this down-regulation was associated with several clinicopathological features such as alpha fetoprotein (AFP) serum level and T stage. Furthermore, we showed with Kaplan-Meier analysis that expression of AGXT2L1 in tumour samples was significantly correlated with patient prognosis. The bioinformatic tool indicated that AGXT2L1 plays a role in the lipid metabolic process of HCC tissue, while siRNA silenced the expression of AGXT2L1 in HCC 97H and LM3 cells, confirming that down-regulation of AGXT2L1 promotes the lipogenesis of cancer cells.

CONCLUSIONS:

For the first time, we have shown that AGXT2L1 is down-regulated in HCC and its low expression indicates a poor prognosis. Our findings also demonstrated that AGXT2L1 is a crucial gene in the abnormal lipogenesis of HCC tissue.

KEYWORDS:

CANCER RESEARCH; LIPIDS; LIVER CANCER; TUMOUR MARKERS

PMID:
26294768
DOI:
10.1136/jclinpath-2015-203042
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center