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Small. 2015 Oct 21;11(39):5200-5. doi: 10.1002/smll.201501370. Epub 2015 Aug 21.

A Compact DNA Cube with Side Length 10 nm.

Author information

1
Physics Department and ZNN/WSI, Technische Universität München, Am Coulombwall 4a, 85748, Garching, Germany.
2
Nanosystems Initiative Munich, Schellingstr. 4, 80799, München, Germany.
3
Wyss Institute for Biologically Inspired Engineering, Harvard University, 3 Blackfan Cir, Boston, MA, 02115, USA.
4
Max Planck Institute of Biochemistry and LMU, Am Klopferspitz 18, 82152, Martinsried, Germany.

Abstract

A small and compact DNA cube with zeptoliter volume is constructed by means of a generalized DNA brick concept using short synthetic oligonucleotides with varying lengths. By mimicking design principles from the DNA origami technique, the DNA cube offers higher stability and assembly yields compared to other approaches. Its potential application as nanoscale fluorescent probe is demonstrated using super-resolution imaging.

KEYWORDS:

DNA bricks; DNA nanostructures; DNA-PAINT; super-resolution microscopy

PMID:
26294348
PMCID:
PMC4707664
DOI:
10.1002/smll.201501370
[Indexed for MEDLINE]
Free PMC Article

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