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Thromb Haemost. 2015 Aug 31;114(3):449-58. doi: 10.1160/TH14-12-1067. Epub 2015 Aug 13.

The role of platelets in inflammation.

Author information

1
Dr. Mark R. Thomas, BMedSci BMBS MRCP, Department of Cardiovascular Science, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK, Tel.: +44 114 3052019, Fax: +44 114 2266159, E-mail markthomas@doctors.org.uk.

Abstract

There is growing recognition of the critical role of platelets in inflammation and immune responses. Recent studies have indicated that antiplatelet medications may reduce mortality from infections and sepsis, which suggests possible clinical relevance of modifying platelet responses to inflammation. Platelets release numerous inflammatory mediators that have no known role in haemostasis. Many of these mediators modify leukocyte and endothelial responses to a range of different inflammatory stimuli. Additionally, platelets form aggregates with leukocytes and form bridges between leukocytes and endothelium, largely mediated by platelet P-selectin. Through their interactions with monocytes, neutrophils, lymphocytes and the endothelium, platelets are therefore important coordinators of inflammation and both innate and adaptive immune responses.

KEYWORDS:

Platelets; immune response; infection; inflammation; thrombosis

PMID:
26293514
DOI:
10.1160/TH14-12-1067
[Indexed for MEDLINE]

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