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Nat Commun. 2015 Aug 21;6:8133. doi: 10.1038/ncomms9133.

Automated adaptive inference of phenomenological dynamical models.

Author information

1
Center for Complexity and Collective Computation, Wisconsin Institute for Discovery, University of Wisconsin, Madison, Wisconsin 53715, USA.
2
Department of Physics, Emory University, Atlanta, Georgia 30322, USA.
3
Department of Biology, Emory University, Atlanta, Georgia 30322, USA.

Abstract

Dynamics of complex systems is often driven by large and intricate networks of microscopic interactions, whose sheer size obfuscates understanding. With limited experimental data, many parameters of such dynamics are unknown, and thus detailed, mechanistic models risk overfitting and making faulty predictions. At the other extreme, simple ad hoc models often miss defining features of the underlying systems. Here we develop an approach that instead constructs phenomenological, coarse-grained models of network dynamics that automatically adapt their complexity to the available data. Such adaptive models produce accurate predictions even when microscopic details are unknown. The approach is computationally tractable, even for a relatively large number of dynamical variables. Using simulated data, it correctly infers the phase space structure for planetary motion, avoids overfitting in a biological signalling system and produces accurate predictions for yeast glycolysis with tens of data points and over half of the interacting species unobserved.

PMID:
26293508
PMCID:
PMC4560822
DOI:
10.1038/ncomms9133
[Indexed for MEDLINE]
Free PMC Article

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