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J Biol Phys. 2016 Jan;42(1):107-32. doi: 10.1007/s10867-015-9395-y. Epub 2015 Aug 21.

Multiscale modeling of tumor growth induced by circadian rhythm disruption in epithelial tissue.

Author information

1
Theoretical Physics Department, Perm State Humanitarian Pedagogical University, 614990, Perm, Russia.
2
Department of Hospital Pediatrics, Perm State Medical Academy, 614990, Perm, Russia.
3
Department of Chemical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel. andreiz@tx.technion.ac.il.
4
Department of Chemical Engineering, Technion-Israel Institute of Technology, 32000, Haifa, Israel. pismen@technion.ac.il.

Abstract

We propose a multiscale chemo-mechanical model of cancer tumor development in epithelial tissue. The model is based on the transformation of normal cells into a cancerous state triggered by a local failure of spatial synchronization of the circadian rhythm. The model includes mechanical interactions and a chemical signal exchange between neighboring cells, as well as a division of cells and intercalation that allows for modification of the respective parameters following transformation into the cancerous state. The numerical simulations reproduce different dephasing patterns--spiral waves and quasistationary clustering, with the latter being conducive to cancer formation. Modification of mechanical properties reproduces a distinct behavior of invasive and localized carcinoma.

KEYWORDS:

Cancer modeling; Circadian rhythms; Signaling; Systems biology; Time-delay

PMID:
26293211
PMCID:
PMC4713406
DOI:
10.1007/s10867-015-9395-y
[Indexed for MEDLINE]
Free PMC Article

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