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AAPS PharmSciTech. 2016 Jun;17(3):631-9. doi: 10.1208/s12249-015-0376-z. Epub 2015 Aug 21.

Topical Niosome Gel of Zingiber cassumunar Roxb. Extract for Anti-inflammatory Activity Enhanced Skin Permeation and Stability of Compound D.

Author information

1
Division of Pharmaceutical Technology, Faculty of Pharmaceutical Science, Khon Kaen University, Khon Kaen, 40002, Thailand. apriprem@gmail.com.
2
Program in Pharmaceutical Chemistry and Natural Products, Faculty of Pharmaceutical Science, Khon Kaen University, Khon Kaen, 40002, Thailand.
3
Division of Pharmacognosy and Medicinal Chemistry, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, 44150, Thailand.
4
Division of Toxicology, Faculty of Pharmaceutical Science, Khon Kaen University, Khon Kaen, 40002, Thailand.

Abstract

An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded thermal-accelerated decomposition of compound D in the gel (p < 0.05) but did not change the activation energy of compound D. Niosomes enhanced in vitro permeation rate of compound D from the gel. Topical applications of ZC noisome gel gave a faster change in tail flick latency than piroxicam gel and hydrocortisone cream (p < 0.05) while there were insignificant differences in anti-inflammatory activity up to 6 h using croton oil-induced ear edema model in mice (p > 0.05). Thus, encapsulation of ZC extract in niosomes enhanced chemical stability and skin permeation with comparable topical anti-inflammatory effects to steroid and NSAID.

KEYWORDS:

Activation energy; Compound D; Niosomal gel; Topical anti-inflammatory; Zingiber cassumunar

PMID:
26292930
DOI:
10.1208/s12249-015-0376-z
[Indexed for MEDLINE]

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