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J Virol. 2015 Nov;89(21):11159-64. doi: 10.1128/JVI.01742-15. Epub 2015 Aug 19.

Transition toward Human Cytomegalovirus Susceptibility in Early Human Embryonic Stem Cell-Derived Neural Precursors.

Author information

1
Clinical Virology Unit, Hadassah Hebrew University Medical Center and Faculty of Medicine, Jerusalem, Israel Department of Biochemistry and the Chanock Center for Virology, IMRIC, Hadassah Hebrew University Medical Center and Faculty of Medicine, Jerusalem, Israel.
2
The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah Hebrew University Medical Center and Faculty of Medicine, Jerusalem, Israel.
3
Department of Biochemistry and the Chanock Center for Virology, IMRIC, Hadassah Hebrew University Medical Center and Faculty of Medicine, Jerusalem, Israel.
4
The Hadassah Human Embryonic Stem Cell Research Center, The Goldyne Savad Institute of Gene Therapy and Department of Gynecology, Hadassah Hebrew University Medical Center and Faculty of Medicine, Jerusalem, Israel benr@hadassah.org.il dana.wolf@ekmd.huji.ac.il.
5
Clinical Virology Unit, Hadassah Hebrew University Medical Center and Faculty of Medicine, Jerusalem, Israel benr@hadassah.org.il dana.wolf@ekmd.huji.ac.il.

Abstract

Congenital human cytomegalovirus (HCMV) infection is associated with neurodevelopmental disabilities. To dissect the earliest events of infection in the developing human brain, we studied HCMV infection during controlled differentiation of human embryonic stem cells (hESC) into neural precursors. We traced a transition from viral restriction in hESC, mediated by a block in viral binding, toward HCMV susceptibility in early hESC-derived neural precursors. We further revealed the role of platelet-derived growth factor receptor alpha (PDGFRα) as a determinant of the developmentally acquired HCMV susceptibility.

PMID:
26292329
PMCID:
PMC4621109
DOI:
10.1128/JVI.01742-15
[Indexed for MEDLINE]
Free PMC Article

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