Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans

Pharmacol Res. 2015 Oct:100:228-41. doi: 10.1016/j.phrs.2015.08.009. Epub 2015 Aug 18.

Abstract

The pharmacological activation of stress-defense mechanisms is one of the perspective ways to increase human lifespan. The goal of the present study was to study the effects on lifespan of Drosophila melanogaster and Caenorhabditis elegans of two carotenoids: ß-carotene and fucoxanthin, which are bioactive natural substances in human diet. In addition, the effects of carotenoids on the flies survival were studied under stress conditions, including starvation, thermal stress (35°C), oxidative stress (20 mM paraquat), as well as locomotor activity, fecundity, and genes expression level. Our results demonstrated lifespan extension of flies by both carotenoids. However, the positive effects on the lifespan of C. elegans were revealed only for fucoxanthin. In presence of carotenoids decreased flies' fecundity, increased spontaneous locomotor activity and resistance to oxidative stress were detected.

Keywords: Aging; C. elegans; D. melanogaster; Fucoxanthin; Fucoxanthin (PubChem CID: 5364094); Lifespan; Stress resistance; β-carotene; β-carotene (PubChem CID: 5280489).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caenorhabditis elegans / drug effects*
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans / physiology*
  • Carotenoids / metabolism
  • Drosophila melanogaster / drug effects*
  • Drosophila melanogaster / metabolism
  • Drosophila melanogaster / physiology*
  • Female
  • Longevity / drug effects*
  • Male
  • Motor Activity / drug effects
  • Oxidative Stress / drug effects
  • Xanthophylls / pharmacology*

Substances

  • Xanthophylls
  • fucoxanthin
  • Carotenoids