Format

Send to

Choose Destination
Neuron. 2015 Aug 19;87(4):673-5. doi: 10.1016/j.neuron.2015.08.013.

Unravelling Spinal Circuits of Pain and Mechanical Allodynia.

Author information

1
Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
2
Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. Electronic address: rohini.kuner@pharma.uni-heidelberg.de.

Abstract

How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underlying mechanical allodynia.

PMID:
26291151
DOI:
10.1016/j.neuron.2015.08.013
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center