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Eur J Cancer Prev. 2016 Sep;25(5):388-94. doi: 10.1097/CEJ.0000000000000203.

Coffee prevents proximal colorectal adenomas in Japanese men: a prospective cohort study.

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aDepartment of Food Nutrition, Faculty of Agriculture, Ryukoku University, Shiga bDepartment of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto cResearch Center for Cancer Prevention and Screening, National Cancer Center, Epidemiology and Prevention Division, Tokyo dGraduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka eDepartment of Hygiene and Public Health, Osaka Medical College fDepartment of Molecular Pathology, Osaka University Graduate School of Medicine & Health Science, Osaka, Japan.


This prospective cohort study aimed to show that coffee prevents the recurrence of colorectal tumors (adenomas, precursors of colorectal cancer, and early-stage colorectal cancers) as well as colorectal cancer. The present study included 307 patients who participated in a clinical study that required endoscopy to remove a colorectal tumor. The amount of coffee consumed by the patients at study inclusion and the frequency of colorectal tumors, as detected by colonoscopy over the subsequent 4 years, were assessed. Coffee consumption was determined using a diet survey that included 3-consecutive-day food records. The risk of colorectal tumor recurrence was significantly lower (odds ratio=0.21; 95% confidence interval, 0.06-0.74) in patients who consumed more than three cups of coffee per day compared with those who consumed no coffee. No correlation was observed between the examined factors, including green tea and black tea intake and the amount of caffeine consumed. In subanalysis divided by the tumor location within the colorectum, the odds ratio of colorectal tumor recurrence in the proximal colon showed a tendency toward reduction as coffee consumption increased; however, increased coffee consumption significantly increased colorectal tumor recurrence in the distal colon. We showed that high coffee consumption reduced the overall occurrence of colorectal tumors, affected by the reduction in the proximal colon.

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