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J Invest Dermatol. 2015 Nov;135(11):2577-2583. doi: 10.1038/jid.2015.295. Epub 2015 Jul 29.

Skin Disease in Laminopathy-Associated Premature Aging.

Author information

1
Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.
2
Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden. Electronic address: Maria.Eriksson.2@ki.se.

Abstract

The nuclear lamina, a protein network located under the nuclear membrane, has during the past decade found increasing interest due to its significant involvement in a range of genetic diseases, including the segmental premature aging syndromes Hutchinson-Gilford progeria syndrome, restrictive dermopathy, and atypical Werner syndrome. In this review we examine these diseases, some caused by mutations in the LMNA gene, and their skin disease features. Advances within this area might also provide novel insights into the biology of skin aging, as recent data suggest that low levels of progerin are expressed in unaffected individuals and these levels increase with aging.

PMID:
26290387
DOI:
10.1038/jid.2015.295
[Indexed for MEDLINE]
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