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Nat Rev Cancer. 2015 Sep;15(9):515-27. doi: 10.1038/nrc3983. Epub 2015 Aug 20.

The dynamic control of signal transduction networks in cancer cells.

Author information

1
Systems Biology Ireland, University College Dublin.
2
Conway Institute of Biomolecular &Biomedical Research, University College Dublin.
3
School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.
4
Roche Moscow Limited, Business Center Neglinnaya Plaza, Building 2, Trubnaya Square, 107031 Moscow, Russia.

Abstract

Cancer is often considered a genetic disease. However, much of the enormous plasticity of cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and to withstand therapeutic assaults is encoded by the structure and spatiotemporal dynamics of signal transduction networks. In this Review, we discuss recent concepts concerning how the rich signalling dynamics afforded by these networks are regulated and how they impinge on cancer cell proliferation, survival, invasiveness and drug resistance. Understanding this dynamic circuitry by mathematical modelling could pave the way to new therapeutic approaches and personalized treatments.

PMID:
26289315
DOI:
10.1038/nrc3983
[Indexed for MEDLINE]

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