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Aging Cell. 2015 Dec;14(6):921-3. doi: 10.1111/acel.12389. Epub 2015 Aug 20.

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

Author information

1
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
2
European University of Madrid, Madrid, Spain.
3
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
4
Research Institute 'Dr. Viña Giner', Molecular and Mitochondrial Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.
5
School of Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.
6
Center for Supercentenarian Study, Keio University School of Medicine, Tokyo, Japan.

Abstract

Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people.

KEYWORDS:

aging; centenarians; longevity gene; longevity regulation; mitochondria; mitochondrial DNA; mitochondrial DNA abnormalities; molecular biology of aging

PMID:
26289118
PMCID:
PMC4693465
DOI:
10.1111/acel.12389
[Indexed for MEDLINE]
Free PMC Article

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