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Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(4):30-35. doi: 10.17116/jnevro20151154130-35.

[A role of melatonin in the treatment of low back pain].

[Article in Russian; Abstract available in Russian from the publisher]

Author information

1
Sechenov First Moscow State Medical University, Moscow.

Abstract

in English, Russian

OBJECTIVE:

To study an analgesic role of melatonin in the treatment of low back pain.

MATERIAL AND METHODS:

A study included 178 patients, aged from 40 to 65 years, with low back pain during at least 12 weeks and the VAS score > 3. Patients were stratified into 6 groups (3 pairs of comparison). In the first pair, patients of the main group (n = 31) received APTPA (a combination of 500 mg of glucosamine hydrochloride and 500 mg of chondroitin sulfate) in dosage 1 tablet twice a day during 1 month and then 1 tablet during 2 months plus melaxen (3 mg of melatonin 30-40 min before sleep), patients of the control group (n = 29) received only APTPA. In the second pair, patients of the comparison group (n = 30) received APTPA in dosage 1 tablet twice a day and diclofenac in dosage 25 mg 2-3 times a day, patients of the main group (n = 30) received additionally melaxen (3 mg of melatonin 30-40 min before sleep). In the third pair, patients of the main group (n = 29) received APTPA in dosage 1 tablet twice a day, diclofenac in dosage 25 mg 2-3 times a day and melaxen (3 mg of melatonin 30-40 min before sleep), patients of the comparison group (n = 29) did not receive melaxen. Treatment results were assessed after 3 months for the first pair and after 1 month for the second and third pairs.

RESULTS:

A significant reduction in pain intensity at movement and resting state was noted in the main groups compared to controls.

CONCLUSION:

Possible mechanisms of analgesic properties of melatonin and world experience in chronic low back pain treatment are discussed.

PMID:
26288285
DOI:
10.17116/jnevro20151154130-35
[Indexed for MEDLINE]

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