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Immunity. 2015 Aug 18;43(2):213-5. doi: 10.1016/j.immuni.2015.08.004.

POPsicle for Fever! Cooling Down the Inflammasome.

Author information

1
Departments of Biomedical Sciences and Pediatrics, Divisions of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
2
Departments of Biomedical Sciences and Pediatrics, Divisions of Infectious Diseases and Immunology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: moshe.arditi@cshs.org.

Abstract

Inhibition of the inflammasome might be beneficial for numerous inflammatory pathologies. In this issue of Immunity, de Almeida et al. (2015) report that the PYRIN domain-only protein (POP1) efficiently inhibits inflammasome activation, identifying it as a pan-inflammasome inhibitor.

PMID:
26287676
DOI:
10.1016/j.immuni.2015.08.004
[Indexed for MEDLINE]
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