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Int J Mol Sci. 2015 Aug 14;16(8):19153-69. doi: 10.3390/ijms160819153.

Current Status on Stem Cells and Cancers of the Gastric Epithelium.

Author information

1
Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany. werner.hoffmann@med.ovgu.de.

Abstract

Gastric cancer is still a leading cause of cancer-related mortality worldwide in spite of declining incidence. Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within the last years, it became clear that gastric self-renewal and carcinogenesis are intimately linked, particularly during chronic inflammatory conditions. Generally, gastric cancer is now regarded as a disease resulting from dysregulated differentiation of stem and progenitor cells, mainly due to an inflammatory environment. However, the situation in the stomach is rather complex, consisting of two types of gastric units which show bidirectional self-renewal from an unexpectedly large variety of progenitor/stem cell populations. As in many other tumors, cancer stem cells have also been characterized for gastric cancer. This review focuses on the various gastric epithelial stem cells, how they contribute to self-renewal and which routes are known to gastric adenocarcinomas, including their stem cells.

KEYWORDS:

Helicobacter pylori; SPEM; cancer stem cell; cell differentiation; gastric cancer; gastric mucosa; gastric self-renewal; gastric stem cell; metaplasia

PMID:
26287172
PMCID:
PMC4581291
DOI:
10.3390/ijms160819153
[Indexed for MEDLINE]
Free PMC Article

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