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J Clin Pathol. 2015 Nov;68(11):879-82. doi: 10.1136/jclinpath-2014-202705. Epub 2015 Aug 18.

Getting controls under control: the time is now for immunohistochemistry.

Author information

1
Department of Laboratory Hematology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Canadian Immunohistochemistry Quality Control (CIQC), Vancouver, BC, Canada.
2
Department of Clinical Medicine, Institute of Pathology, Aalborg University Hospital, Aalborg, Denmark Nordic Immunohistochemical Quality Control (NordiQC), Aalborg, Denmark.
3
Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Abstract

For several decades, immunohistochemistry (IHC), more specifically diagnostic IHC (dIHC), has been considered an art rather than a laboratory test. There was no clarity about what test performance characteristics are relevant to dIHC, test performance characteristics were not fully defined for dIHC and partly as a consequence of that, there were no standardised controls or reference standards. Herein, we discuss the role of standardisation of external controls for test performance characteristics and the role of standardised controls and reference standards for overall standardisation of IHC.

KEYWORDS:

IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; QUALITY CONTROL; STAINING

PMID:
26286753
PMCID:
PMC4680144
DOI:
10.1136/jclinpath-2014-202705
[Indexed for MEDLINE]
Free PMC Article

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