Albuterol Delivery via Facial and Tracheostomy Route in a Model of a Spontaneously Breathing Child

Respir Care. 2015 Dec;60(12):1749-58. doi: 10.4187/respcare.04142. Epub 2015 Aug 18.

Abstract

Background: Some pediatric patients receiving therapeutic aerosols undergo tracheostomy, and others who are tracheostomized continue requiring inhaled therapies upon decannulation. It is unknown whether a dose adjustment is required. Different devices are available for facial and tracheostomy delivery, and in some instances, the assisted technique is used. We hypothesized that the change from face mask to tracheostomy would result in a decrease in the lung dose.

Methods: A breathing simulator connected in series to a filter holder and an anatomically correct head model of a child was used. The drug captured in the filter was termed the lung dose. Breathing patterns with tidal volumes of 50, 155, and 300 mL were tested. Albuterol hydrofluoroalkane (pressurized metered-dose inhaler [pMDI]) with an AeroChamber Mini (face and 4.5-mm tracheostomy), AeroTrach (4.5-mm tracheostomy), and AeroChamber (face) and albuterol (2.5 mg/3 mL) with a continuous output nebulizer (face and 4.5-mm tracheostomy) were tested. Masks were used for facial delivery. Four units of each device were tested. Particle size of the pMDI was measured by cascade impaction. Albuterol concentration was determined via spectrophotometry (276 nm).

Results: Switching from facial to tracheostomy delivery increased lung dose with nebulizer (all breathing patterns). When a pMDI was used, lung dose was unchanged or increased for the 50- and 155-mL and decreased for the 300-mL breathing pattern. The use of the assisted technique increased lung dose only during nebulization with the 300-mL breathing pattern. The particle size of the pMDI decreased by 19-23% when traveling through the tracheostomy tube, which retained < 4% and < 26% of the nominal dose of a nebulizer and pMDI, respectively.

Conclusions: The effect of changing the delivery route from face to tracheostomy was variable and depended on the delivery device and the breathing pattern. There is no advantage of using the assisted technique to enhance aerosol delivery.

Keywords: aerosol; artificial airway; drug delivery; jet nebulizer; metered dose inhaler; tracheostomy; valved-holding chamber.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Aerosols / administration & dosage
  • Albuterol / administration & dosage*
  • Bronchodilator Agents / administration & dosage*
  • Child
  • Drug Delivery Systems / instrumentation
  • Drug Delivery Systems / methods*
  • Face
  • Humans
  • Masks*
  • Metered Dose Inhalers*
  • Models, Anatomic
  • Models, Theoretical
  • Particle Size
  • Respiration
  • Tidal Volume
  • Tracheostomy*

Substances

  • Aerosols
  • Bronchodilator Agents
  • Albuterol