Format

Send to

Choose Destination
Eur Child Adolesc Psychiatry. 2016 May;25(5):509-18. doi: 10.1007/s00787-015-0759-4. Epub 2015 Aug 19.

Interactive effects of BDNF Val66Met genotype and trauma on limbic brain anatomy in childhood.

Author information

1
Merrill Palmer Skillman Institute for Child and Family Development, Wayne State University, 71 E. Ferry Street, Detroit, MI, 48202, USA.
2
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
3
Liberty University College of Osteopathic Medicine, Lynchburg, VA, USA.
4
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
5
Brain and Creativity Institute, University of Southern California, Los Angeles, CA, USA.
6
Signal and Image Processing Institute, University of Southern California, Los Angeles, CA, USA.
7
Department of Radiology, Wayne State University, Detroit, MI, USA.
8
Merrill Palmer Skillman Institute for Child and Family Development, Wayne State University, 71 E. Ferry Street, Detroit, MI, 48202, USA. moriah@wayne.edu.
9
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA. moriah@wayne.edu.
10
Perinatology Research Branch, NICHD/NIH/DHSS, Detroit, MI, USA. moriah@wayne.edu.

Abstract

Childhood trauma is a major precipitating factor in psychiatric disease. Emerging data suggest that stress susceptibility is genetically determined, and that risk is mediated by changes in limbic brain circuitry. There is a need to identify markers of disease vulnerability, and it is critical that these markers be investigated in childhood and adolescence, a time when neural networks are particularly malleable and when psychiatric disorders frequently emerge. In this preliminary study, we evaluated whether a common variant in the brain-derived neurotrophic factor (BDNF) gene (Val66Met; rs6265) interacts with childhood trauma to predict limbic gray matter volume in a sample of 55 youth high in sociodemographic risk. We found trauma-by-BDNF interactions in the right subcallosal area and right hippocampus, wherein BDNF-related gray matter changes were evident in youth without histories of trauma. In youth without trauma exposure, lower hippocampal volume was related to higher symptoms of anxiety. These data provide preliminary evidence for a contribution of a common BDNF gene variant to the neural correlates of childhood trauma among high-risk urban youth. Altered limbic structure in early life may lay the foundation for longer term patterns of neural dysfunction, and hold implications for understanding the psychiatric and psychobiological consequences of traumatic stress on the developing brain.

KEYWORDS:

Adolescence; Brain-derived neurotrophic factor; Early adversity; Gray matter volume; Medial prefrontal cortex; Mood disorders

PMID:
26286685
PMCID:
PMC4760899
DOI:
10.1007/s00787-015-0759-4
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center