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Neuropsychopharmacology. 2016 Jan;41(1):219-31. doi: 10.1038/npp.2015.249. Epub 2015 Aug 18.

Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice.

Author information

1
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.
2
Department of Psychiatry and Behavioral Sciences and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
3
Howard Hughes Medical Institute, Chevy Chase, MD, USA.

Abstract

Trajectories toward risk or resilience in psychiatric disorders are influenced by acquired and inherited factors. More recently, evidence from rodent studies suggest that acquired risk factors can be transmitted through non-genomic, epigenetic mechanisms to subsequent generations, potentially contributing to a cycle of disease and disease risk. Here, we review examples of transmission of environmental factors across generations and illustrate the difference between behavioral transmission and epigenetic inheritance. We highlight essential definitions of intergenerational and transgenerational transmission of disease risk with corresponding examples. We then explore how these phenomena may influence our understanding of psychiatric disorders leading toward new prevention and therapeutic approaches.

PMID:
26283147
PMCID:
PMC4677139
DOI:
10.1038/npp.2015.249
[Indexed for MEDLINE]
Free PMC Article

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