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J Clin Pathol. 2016 Mar;69(3):209-14. doi: 10.1136/jclinpath-2015-202985. Epub 2015 Aug 17.

High Ki67 expression is an independent good prognostic marker in colorectal cancer.

Author information

1
Department of Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
3
Department of Oncology, Hematology, BMT with section Pneumology, Hubertus Wald Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
4
Institute of Pathology, University Hospital Basel, Basel, Switzerland.

Abstract

AIMS:

To correlate Ki67 expression with outcome in colorectal cancer (CRC).

METHODS:

Ki67 labelling index (Ki67LI) was analysed by immunohistochemistry on a tissue microarray containing 1800 CRCs. The results were compared with clinicopathological and molecular parameters.

RESULTS:

Ki67LI was considered low in 26.3%, moderate in 56.7% and high in 17.0% of 1653 interpretable CRCs. High Ki67 expression was associated with low tumour stage (p<0.0001) and nodal status (p=0.0315), but not with tumour grade (p=0.8639), histological tumour type (p=0.1542) or tumour localisation, and was an independent prognosticator of favourable survival (p=0.0121). High Ki67 expression was also significantly associated with high-level nuclear β-catenin and p53 expression (p<0.0001 and p=0.0095, respectively).

CONCLUSIONS:

In summary, our data show that high Ki67 expression in CRCs is associated with good clinical outcome. Ki67, p53 and β-catenin overexpression seem to be linked to CRC, and indicate a cellular state of high proliferative activity. Finally, our findings strongly argue for a clinical utility of Ki67 immunostaining as an independent prognostic biomarker in CRC.

KEYWORDS:

ANTIBODIES; CANCER RESEARCH; COLORECTAL CANCER; KI 67; MOLECULAR PATHOLOGY

PMID:
26281861
DOI:
10.1136/jclinpath-2015-202985
[Indexed for MEDLINE]
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