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Nat Genet. 2015 Oct;47(10):1158-1167. doi: 10.1038/ng.3381. Epub 2015 Aug 17.

Absence of canonical marks of active chromatin in developmentally regulated genes.

Author information

1
Centre for Genomic Regulation. Barcelona, Catalonia, Spain.
2
Universitat Pompeu Fabra. Barcelona, Catalonia, Spain.
3
Departament de Genètica (Facultat de Biologia) , Universitat de Barcelona. Barcelona, Catalonia, Spain.
4
Institut de Biomedicina de la Universitat de Barcelona. Barcelona, Catalonia, Spain.
5
Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.
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Contributed equally

Abstract

The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results support a model in which chromatin marking is associated with the stable production of RNA, whereas unmarked chromatin would permit rapid gene activation and deactivation during development. In the latter case, regulation by transcription factors would have a comparatively more important regulatory role than chromatin marks.

PMID:
26280901
PMCID:
PMC4625605
DOI:
10.1038/ng.3381
[Indexed for MEDLINE]
Free PMC Article

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