Send to

Choose Destination
Curr Trop Med Rep. 2015 Jun 1;2(2):90-99.

Cryptococcal Meningitis: Diagnosis and Management Update.

Author information

University of Minnesota, Minneapolis, MN, USA ; Infectious Disease Institute, Makerere University, Kampala, Uganda.
University of Minnesota, Minneapolis, MN, USA.


Recent advances in the diagnosis and management of cryptococcal meningitis are promising and have been improving long-term survival. Point of care testing has made diagnosing cryptococcal meningitis rapid, practical, and affordable. Targeted screening and treatment programs for cryptococcal antigenemia are a cost effective method for reducing early mortality on antiretroviral therapy (ART). Optimal initial management with amphotericin and flucytosine improves survival against alternative therapies, although amphotericin is difficult to administer and flucytosine is not available in middle or low income countries, where cryptococcal meningitis is most prevalent. Controlling increased intracranial pressure with serial therapeutic lumbar punctures has a proven survival benefit. Delaying ART initiation for 4 weeks after the diagnosis of cryptococcal meningitis is associated with improved survival. Fortunately, new approaches have been leading the way toward improving care for cryptococcal meningitis patients. New trials utilizing different combinations of antifungal therapy are reviewed, and we summarize the efficacy of different regimens.


AIDS; Antifungal therapy; Antiretroviral therapy; CM-IRIS; Cryptococcal meningitis; HIV; Immune reconstitution inflammatory syndrome; Review

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center