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Cell Rep. 2015 Aug 25;12(8):1217-25. doi: 10.1016/j.celrep.2015.07.042. Epub 2015 Aug 13.

Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway.

Author information

1
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.
2
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.
3
Department of Immunology and Microbiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
4
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: aneish@emory.edu.

Abstract

An optimal gut microbiota influences many beneficial processes in the metazoan host. However, the molecular mechanisms that mediate and function in symbiont-induced host responses have not yet been fully characterized. Here, we report that cellular ROS enzymatically generated in response to contact with lactobacilli in both mice and Drosophila has salutary effects against exogenous insults to the intestinal epithelium via the activation of Nrf2 responsive cytoprotective genes. These data show that the xenobiotic-inducible Nrf2 pathway participates as a signaling conduit between the prokaryotic symbiont and the eukaryotic host. Indeed, our data imply that the capacity of lactobacilli to induce redox signaling in epithelial cells is a highly conserved hormetic adaptation to impel cellular conditioning to exogenous biotic stimuli. These data also highlight the role the microbiota plays in eukaryotic cytoprotective pathways and may have significant implications in the characterization of a eubiotic microbiota.

PMID:
26279578
PMCID:
PMC4640184
DOI:
10.1016/j.celrep.2015.07.042
[Indexed for MEDLINE]
Free PMC Article

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